Enzymatic incorporation of LNA nucleotides into DNA strands.
نویسندگان
چکیده
Oligonucleotides composed of naturally occurring nucleic acids are unsuitable for many therapeutic and biotechnological applications because of their poor biostability. Numerous nucleic acid analogues have therefore been synthesized for applications related to target-validation studies or therapeutic molecules. Locked nucleic acid (LNA) nucleotide monomers are nucleic acid analogues with a fixed C3’-endo/N-type furanose conformation that mimics the ribose conformation of A-type helical RNA (Scheme 1). LNA-modified DNA/RNA oligonucle-
منابع مشابه
Enzymatic synthesis of DNA strands containing α-L-LNA (α-L-configured locked nucleic acid) thymine nucleotides
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عنوان ژورنال:
- Chembiochem : a European journal of chemical biology
دوره 8 5 شماره
صفحات -
تاریخ انتشار 2007